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“This indication provide physician with an conquering and timely psychoanalysis opportunity for appropriate patients with severe hypertension, and provides these patients with a treatment assessment sensationally more handy than taking two standing apart tablets,” said George L. Bakris, M.D., F.A.C.P., F.C.P., administrator, Hypertension/Clinical Research Center, Rush University Medical Center in Chicago.

Pulmonary Hypertension (PH) be hardened and life-shortening vascular virus characterized by elevated constant worry in the lung vein central to putting in place heart letdown. In a translational research try realize the “bench to bedside” assessment, a troop of physician led by Prof. Friedrich Grimminger and Dr. Ardeschir Ghofrani organized the “Giessen Everest Experiment” next to the aim to further inquest the therapeutic promise of sildenafil (Viagra™) in human: The shift observed in stout mountaineers simulate disease process in patients agony from chronic lung disease. This high altitude study logically standard the selective pulmonary vasodilatory effect of sildenafil. The objects humidify pulmonary hypertension, improve gas switch and increase exert dimensions. Further clinical study in Giessen in patients suffering from divergent form of PH (adults, offspring and infants) have confirmed these grades and commander to an multinational multicenter study. The results of this sizeable randomized, double-blind, placebo-controlled study were artistic presented by Giessen scientists at the World Conference of the American College of Chest Physicians in September 2004. The bloc published the results of their studies in pulmonary hypertension in illustrious proven journal such as “Nature Medicine”, “Annals of Internal Medicine”, Lancet” and “New England Journal of Medicine”.

University of Giessen Lung Center (UGLC)

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